Algerian Journal of Pharmaceutical Engineering
Volume 0, Numéro 0, Pages 24-29
2023-03-30

Carnauba Wax As A Promising Excipient In Melt Granulation Targeting The Preparation Of Tablets For Sustained Release Of Highly Soluble Antihyperglycemic Drug



Authors : Lefnaoui Sonia . Yahoum Madiha Melha .

Abstract

The main aim of this study is to formulate sustained release (SR) matrix tablets of Metformin hydrochloride (MF) using carnauba wax (CW) as hydrophobic carriers by the way of hot melt granulation method. The meltable binder CW was used at fractions of 10%, 20%, 30% and 40% of the total weight of the tablet. The influence of a hydrophilic polymer, Xanthan gum (XG, 10%) on the waxy matrices was studied. The compression granules beds were studied for their rheological behavior. The granules for tableting were evaluated for their micromeritic properties such as particle size, Angle of repose, bulk density, tapped density, Carr's index (CI), Hausner ratio (HR) and flow properties. The results showed satisfactory flow properties with increasingly close packing with increase in the amounts of CW incorporated. The FTIR spectral analysis revealed no interactions between drug and polymers. The prepared tablets were subjected to thickness, weight variation test, hardness, and friability and in-vitro release studies. The results demonstrated that all formulations fulfilled the official requirements according to the pharmacopeia standards. From the dissolution studies, it was observed that carnauba wax acts as good retardant (more than 24 h) and can overcome the disadvantages of conventional tablets of Metformin Hydrochloride. The n value obtained from Korsmeyer-Peppas model confirmed that the drug release was non-fickian diffusion mechanism. It was concluded that hydrophobic carriers act as very good retardants of the drug and that XG may be used as a channeling agent in waxy matrices to regulate the release of the drug.

Keywords

Metformin. Carnauba wax. Melt granulation. Tablets. Sustained drug release.

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