Algerian Journal of Pharmaceutical Engineering
Volume 0, Numéro 0, Pages 15-20
2023-03-30
Formulation And Evaluation Of Xanthan Gum Microspheres For The Sustained Release Of Metformine Hydrochloride
Authors : Yahoum Madiha Malha . Lefnaoui Sonia .
Abstract
Purpose The aim of this work was to formulate xanthan gum microspheres for the encapsulation of Metformin hydrochloride according to the process of ionotropic gelation. Methods The obtained microparticles based on various fractions of xanthan gum (0.5-1.25) were subjected to different physic-chemical tests and a drug release study. Results Microspheres with an average size of 206.55μm were obtained. Encapsulation efficiency has reached 93.11% at 1.25% biopolymer concentration. The swelling study showed a swelling rate reaching 29.8% in gastric medium (pH1.2) and 360% in intestinal medium (pH 6.8). The drug release studies showed a complete Metformin hydrochloride release from the beads, especially those prepared from Xanthan Gum at the concentration of 1.25%, in intestinal medium 90.00% after 8 hours. However, limited and insignificant drug release was observed within the gastric medium (32.50%).The dissolution profiles show sustained release kinetics.
Keywords
Xanthan Gum. Metformin chloride. Encapsulation. Gelling. Extended-Release.
Les articles similaires
بوسالم أحلام
.
عابد يوسف
.
ص 117-132.
Yahia Zeghoudi
.
pages 74-88.
Janardhana K. H.
.
Deveswaran R.
.
Bharath S.
.
Basavaraj B. V.
.
Madhavan V.
.
pages 220-239221.
Lefnaoui Sonia
.
Yahoum Madiha Melha
.
pages 24-29.
Said Houari Amel
.
pages 257-268.
