AGROBIOLOGIA
Volume 9, Numéro 2, Pages 1474-1483
2019-12-30

Antihyperlipidemic And Antioxidant Effects Of The Microalgae Nannochloropsis Gaditana In Streptozotocin-induced Diabetic Rats



Authors : Nacer Wassila .

Abstract

Description of the subject: Marine organisms, such as microalgae, have attracted universal interest in the field of research as an alternative source of therapeutic and biological compounds that can be used for treatment of different diseases. Objective: The aim of the present study was to investigate the possible hypoglycemic, hypolipidemic and antioxidant effect of the microalgae Nannochloropsis gaditana in streptozotocin-induced diabetic rats. Methods: Diabetes was induced in male Wistar rats by single intraperitoneal injection of streptozotocin (45 mg/kg). Male rats were fed on control diet supplemented or not with Nannochloropsis gaditana (10%) for two months. At the end of the experiment, plasma and tissues biochemical parameters and oxidant/antioxidant markers were determined. Results: The results obtained in this study show that streptozotocin induced animal diabetes characterized by adverse alterations of the metabolic and the balance oxidant /antioxidant. However, Nannochloropsis gaditana supplementation resulted in a significant reduction in the level of plasma glycated hemoglobin, plasma and tissue lipids and attenuates oxidative stress and thus improves metabolic status. In addition, it induced a modulation of lipase activities in diabetic rats. On the other hand, due to its antioxidant properties, Nannochloropsis gaditana was shown to have the capacity to mitigate the oxidative stress by increasing the antioxidant defense. Conclusion: This study suggests that the microalgae Nannochloropsis gaditana has a beneficial effect in controlling diabetes by reducing blood glucose, lipid profile and oxidative stress, which reduces the risk of developing complications of diabetes.

Keywords

diabète, diabetes, lipid profile, Nannochloropsis gaditana, oxidative stress, profil lipidique, streptozotocin, streptozotocine, stress oxydatif

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