Journal de la Faculté de Médecine
Volume 1, Numéro 2, Pages 177-181
2017-09-30
Authors : Boughrara Wefa . Benzaoui Ahmed . Aberkane Meriem . Moghtit Fatima Zohra .
Abstract Objectives - The aim of this study is to determine the impact of the gamma glutamyl hydrolase (GGH) c.452C>T (dbSNP Id: rs 11545078) polymorphism on the Methotrexate (MTX) adverse drug reactions (ADRs) and on MTX gastro intestinal toxicity (GIT) in rheumatoid arthritis (RA) patients. Materials and methods - Sixty-one patients with RA are enrolled in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Data were analyzed by χ2. Results - Our findings suggest that the frequencies distributions of alleles/genotypes of this polymorphism were similar in both groups with and without ADRs. However, there is a significant distribution of GGH 452TT (p=0.03) and GGH 452CT+452TT (p=0.02) genotypes between the groups with and without GIT. The same correlation was found for GGH 452T allele (p=0.008). Conclusion - We have shown for the first time in the West Algerian population that the GGH c.452C>T polymorphism influences the MTX gastro-intestinal toxicity.
GGH, Methotrexate, Rheumatoid arthritis, Algeria, polymorphism
Cherif Redouane Amine
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Yargui Lyèce
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Slimani Samy
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Aissoug Amel
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Rahmani Salima
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Bouaicha Malika Nawel
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Boukrous Hanane
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pages 46-57.
El Abed Fadia
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Benlebna Freha
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Djaroud Ziania
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pages 71-80.
Abid Ghania
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Messal Ahlem
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Harmel Mohammed
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Missouri Mohammed
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Djadaouadji Iness
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Adda Neggaz Nawel
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Idder Aicha
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Abdi Meriem
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Meroufel Djabaria Naima
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Fodil Mostafa
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Zemani-fodil Faouzia
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pages 41-50.
Labiad Nawal
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Messatfa Moussa
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Bouali-youcef Youcef
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Kadiri Houria
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Ouikhlef Nardjess
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pages 45-52.
Cherif Redouane Amine
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Yargui Lyèce
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Amroune Abdelkader
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Lalaymia Youcef
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Saidi Mahdia
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Ouarhlent Yamina
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pages 50-52.