Algerian Journal of Engineering Research
Volume 2, Numéro 4, Pages 31-35
2018-12-01
Study Of The Effect Of Various Super Disintegrants On Amoxicillin Trihydrate Orally Disintegrating Tablets
Authors : Narimane Lammari . Hadjira Rabti . Wahida Louaer . Abdeslam Hassen. Meniai .
Abstract
Orally disintegrating tablets constitute an innovative approach to overcome the dysphagia in pediatric and geriatric patients and provide a quick onset of action. The current study was aimed to formulate and evaluate an orally disintegrating tablet containing Amoxicillin trihydrate using three types of Superdisintegrants: Croscarmellose sodium, crospovidone and sodium starch glycolate at three different concentrations (0.5, 1 and 2%) by direct compression method. The prepared tablets were evaluated for hardness, friability, weight uniformity, drug content uniformity, and disintegration time and drug dissolution rate. The results showed that Croscarmellose sodium at 0.5% gave a reduced disintegration time of 26s and a very high release rate of 97% in 20 min.
Keywords
Orally disintegrating tablet; Amoxicillin trihydrate; Super disintegrant; Direct compression
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