Synthèse
Volume 14, Numéro 2, Pages 35-44
2008-07-31

Lorsban-induced Changes In Haematological Parameters, Testosterone And Thyroxin Levels, And Semen Quality Of Male Rats



Authors : Mosbah Rachid . Chouabia Amel . Yousef Mokhtar Ibrahim . Boulakoud Mohamed Salah .

Abstract

The present study was carried out to investigate the possible toxic effects of different doses of lorsban on blood parameters, testosterone and thyroxin levels, and semen quality of male rats. Lorsban was administered to rats by oral route at different doses (5, 10 and 15 mg/kg bw/day) for 6-weeks. The obtained results showed that all three doses of Lorsban significantly (p<0.05) lowered the body weight gains. Relative weights of testes, epididymal and seminal vesicles were significantly (p<0.05) decreased in rats receiving 15 mg/kg only. There was also a decrease in mean corpuscular haemoglobin (MCH) and in mean corpuscular volume (MCV) in all experimental animals compared to control ones. While, there were insignificant changes in white blood cells (WBC), haemoglobin (Hb), haematocrit value (Ht), mean cell haemoglobin concentration (MCHC) and red blood cells (RBC) for rats treated with lorsban compared to control group. Meanwhile, it appeared that lorsban caused a rise in thrombocyte (PL) number in individuals treated with the highest dose. Similarly, the highest dose induced a marked (p<0.001) decrease in spermatids number, sperm count and sperm transit rate with an observed impairment of daily sperm production. Such observations were coupled with a reduction in plasma testosterone levels and an increase in plasma free thyroxin (FT4) levels compared to controls. It is, therefore, assumed that treatment with lorsban up to 15 mg/kg bw alters both haematological and endocrinological parameters in rats, and subsequently affects fertility.

Keywords

Rats; Lorsban; haematological parameters; semen quality; testosterone; thyroxin.

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