Algerian Journal of Natural Products
Volume 5, Numéro 1, Pages 417-427
2017-02-03

Antinociceptive Activity Of Methanolic Leaf Extract Of Parthenium Hysterophorus L.



Authors : Sarwar Shammy . Shah Marzia Mahjabin Lina . Md. Shahnewaz Shihab .

Abstract

The present study was aimed to evaluate the antinociceptive property of Parthenium hysterophorus L. The central antinociceptive activity was analyzed by hot plate and tail immersion method; whereas acetic acid-induced writhing test and formalin induced licking tests were carried out for peripheral antinociceptive activity. The acute toxicity study revealed that methanol extract of the plant was moderately toxic at a dose of 500 mg/kg body weight. In hot plate method and tail immersion test the methanol extract exhibited significant analgesic activity ( < 0.001) at a dose of 2.5 and 5 mg/kg revealed its central antinociceptive activity. The significant activity (p<0.01) in acetic acid induced writhing test and formalin induced licking test implies the peripheral antinociceptive property of the extract at both doses. These findings justify that P. hysterophorus L. can be a valuable natural antinociceptive source which seemed to provide potential phytotherapeutics against various ailments.

Keywords

Parthenium hysterophorus L; antinociceptive; morphine

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