Algerian Journal of Sciences
Volume 0, Numéro 0, Pages 62-67
2024-07-04
Synthesis, Characterization And Antimicrobial Activity Of Two α Aminophsphonates Esters Derived From Benzylamine
Authors : Hellal Abdelkader . Bouchama Anis . Layaida Houdheifa . Madani Abdelghani .
Abstract
Synthesis of α-aminophosphonate esters with antimicrobial properties is of great interest in the development of new pharmaceutical products. In this article we present the synthesis of two α-aminophosphonate esters, namely, [(Benzylamino-phenyl-methyl)-phosphonic acid diethyl ester (AM1) and (Benzylamino-p-tolyl-methyl)-phosphonic acid diethyl ester (AM2) under green condition using microwave irradiation. These molecules where then, characterized, and evaluated for their antimicrobial responses. The synthesized compounds were obtained utilizing methylamine, aromatic aldehydes and diethylphosphite via Kabachnik-Fields reaction, as well as their structures were established through spectroscopic methods. Additionally, the results of the preliminary screening indicate that the examined molecule showed potent antimicrobial activity, compared to standard drugs. The results showed reasonable microbial activity against the two gram positive bacteria (Staphylococcus aureus and Streptococcus pyogens) and the two gram negative (Pseudomonas aureginosa and Escherichia coli) as well as two the fungi strains (Aspergillus niger and Candida albicans).
Keywords
α-aminophosphonate esters, Kabachnik-Fields reaction, antimicrobial, microwave irradiation.
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