Algerian Journal of Pharmaceutical Engineering
Volume 0, Numéro 0, Pages 1-4
2023-03-30

Effect Of Formulation Parameters On The Encapsulation Of A Hydrophobic Active Ingredient Obtained By Ionic Gelation



Authors : Lamoudi Lynda . Akreche Soraya . Daoud Kamel .

Abstract

Prednisone, a synthetic hormone belonging to the corticosteroid family, is produced by the adrenal glands. In the medicine, it is known that it is used for its anti-inflammatory properties. In this study it is used as a model hydrophobic active substance for encapsulation by ion gelation. For the optimization of the formulation of these microspheres based on sodium alginate, we carried out a parametric work to study the influence of process and formulation parameters on the encapsulation efficiency of the active ingredient. This research consists in determining the influence sodium alginate concentration, Calcium Chloride concentration and both the quantity and the nature of the surfactants. The aim of the work is to specify the quality of the microspheres obtained (morphology, diameter, surface and efficiency of encapsulated API). The results demonstrated that the prednisone encapsulation ratio depends on several parameters such as the nature and concentration of the polymer used, the crosslinking agent and kind of surfactant. Morphological analysis by optical microscopy and SEM confirms the presence of microparticles of spherical, porous shape and variable sizes. The presence of Prednisone in the microparticles was confirmed by IRTF analysis which revealed the appearance of additional absorption bands characteristic of Prednisone in the IR spectrum of the microparticles.

Keywords

Microencapsulation. ionic gelation. Prednisone, sodium alginate. calcium chloride

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