Revue des Sciences Fondamentales Appliquées
Volume 8, Numéro 1, Pages 176-181
2016-01-01
Authors : Lanez T. . Henni M. .
Spectrophotometric techniques based assay were developed for the determination of binding parameters like binding constant and binding free energy of two potential antioxidants ferrocene derivatives: 2-(ferrocenylmethylamino)benzonitrile (2FMAB), 3-(ferrocenylmethyl-amino)benzonitrile (3FMAB), and a standard ascorbic acid (AA) with 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH). Obtained resultants indicated that the adduct 3FMBA-DPPH shows highest binding constant and highest binding free energy (2.28×105 M-1) and (-30.59 KJmol-1) respectively. Binding free energy of 3FMAB-DPPH is almost three times greater than that of the adduct 2FMAB-DPPH (-10.47 KJmol-1) and also is greater than the adduct formed between the standard antioxidant ascorbic acid and 1,1-diphenyl-2-picrylhydrazyl radicals (AA-DPPH) (-19.29 KJmol-1).
ferrocene derivatives, DPPH, binding parameters, binding free energy, binding constant.
Sirry Shadia Mahmoud
.
Babiker Hind Ahmed
.
pages 562-572.
Chouikh Atef
.
Rebiai Abdelkrim
.
Aref Mahdia
.
Heded Mounira
.
Adjal El Hadda
.
Alia Fatma
.
pages 14-17.
يحيى باي خديجة
.
ص 324-356.
Almunif Sarah
.
pages 22-35.
Bouzidi N.
.
Seridi H.
.
Daghbouche Y.
.
El Hattab M.
.
pages 26-32.