Journal de la Faculté de Médecine
Volume 1, Numéro 1, Pages 43-47
2017-06-30

Résultats Préliminaires De L’effet Du Polymorphisme Xrcc3 Thr241met Sur La Susceptibilité Au Cancer De La Prostate Dans La Population De L’ouest Algérien: Etude Cas-témoins



Auteurs : Boughrara Wefa . Aberkane Meriem . Benabdellah Hamza . Makrelouf Mohamed Yacine Abdelwahid .

Résumé

Abstract Objective - In Algeria, prostate cancer (PC) is a real public health problem. Our study consists in determining the influence of the polymorphism Thr241Met of the XRCC3 gene on the susceptibility to develop a PC. To this end, we undertook a case-control study of this polymorphism in a sample of the Algerian West population. Materials and methods - This case-control study involved 10 subjects with PC and 20 unrelated healthy subjects. The various genotypes of the polymorphism were investigated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The comparison of allelic and genotypic frequencies between the two groups was established by calculating the odds ratio (OR) with a 95% confidence interval. Results - In this preliminary exploration, statistical analysis showed that there was no statistically significant difference in the distribution of allelic and genotypic frequencies (OR = 0.36 [0.12-1.1], P = 0.7) of the polymorphism explored between cases and controls in this first sample of the population explored. Conclusion - In conclusion, we consider increasing the size of the sample to be studied to confirm this lack of association. On the other hand, we believe that it is important to explore other polymorphisms located not only on the XRCC3 gene but also on other genes involved in DNA repair in order to enhance genetic characterization of PC in the western Algerian population.

Mots clés

Cancer; XRCC3; Thr 241 Met; PCR; Algerian population.

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